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KMID : 0525720140190010040
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Journal of Chitin and Chitosan
2014 Volume.19 No. 1 p.40 ~ p.46
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Percutaneous Absorption Characteristics of Niacinamide using Sodium Alginate and Chitosan
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Um Mi-Sun
Moon Ki-Seop
Chai Ji-Hae
Chung Kwang-Bo
Lee Han-Seob
Jung Byung-Ok
Chung Suk-Jin
Kim Kyung-Ho
Won Sung-kwon
Kim Dong-Kwon
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Abstract
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Drug delivery technologies are protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as user convenience and compliance. The most commonly used transdermal system is the skin patch and gel using various types of technologies. Compared with other method of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage if the drug dosage lead to side effect. In this study, Polysaccharide, such as chitosan and sodium alginate were selected as base materials for Percutaneous Absorption. Also, these natural polymers were characterized in terms of enhancers, niacinamide contents. Among these polysaccharide, the permeation rate of chitosan matrix was fastest in Niacin amide such as hydrophilic material in vitro. We used glycerin, PEG 400 and 800 as enhancers. Therefore, transdermal absorption of niacinamide could be improved by changing vehicle composition or using penetration enhancers. Especially it would be anticipated that the high permeation efficacy could be obtained using vehicle that has enhancing effect for itself and by adding enhancers to it.
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KEYWORD
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Niacinamide, Natural polymer, Percutaneous absorption, Permeation rate, Enhancer
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